Aspirin causes rapid up-regulation of cyclo-oxygenase-2 expression in the stomach of rats
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چکیده
منابع مشابه
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Introduction: Leukemia is considered one of the main causes of death, and current chemotherapeutic agents are unable to provide optimal responses due to chemo-resistance. Therefore, there is a constant need for new drugs. Cyclooxygenase- 2 (COX-2) inhibitors can be helpful by reducing the necessary dose of routine chemotherapeutic drugs. Herein, we evaluated the cytotoxicity activity as well...
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BACKGROUND There are two isoforms of cyclo-oxygenase (COX), namely COX-1 and COX-2. COX-1 is constitutively expressed in most tissues and in blood platelets. The metabolites derived from COX-1 are probably involved in cellular housekeeping functions. COX-2 is expressed only following cellular activation by inflammatory stimuli and is thought to be involved in inflammation. METHODS The express...
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ژورنال
عنوان ژورنال: Alimentary Pharmacology and Therapeutics
سال: 1997
ISSN: 0269-2813,1365-2036
DOI: 10.1046/j.1365-2036.1997.00247.x